rat INSIG1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Insig1.
shADV-290833
Ad-r-INSIG1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Insig1 (insulin induced gene 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.
Gene ID
64194
Gene Name (Vector)
insulin induced gene 1
Gene Symbol
Insig1
ORF Size (aa)
780
RefSeq ID
NM_022392
RefSeq Synonyms
NM_022392, BC078827,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.