rat PRNP shRNA silencing Adenovirus

Name
Ad-r-PRNP-shRNA

Cat No
shADV-290717

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Rat Prnp.

shADV-290717

Ad-r-PRNP-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Rat Prnp (prion protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

Prn; PrP

Description (Vector)

PRNP may play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).

Gene ID

24686

Gene Name (Vector)

prion protein

Gene Symbol

Prnp

ORF Size (aa)

765

RefSeq ID

NM_012631

RefSeq Synonyms

NM_012631, BC072692,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.