rat RUVBL1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Ruvbl1.
shADV-290696
Ad-r-RUVBL1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Ruvbl1 (RuvB-like AAA ATPase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NMP238; Pontin52; Tip49a
Description (Vector)
Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity|Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage|Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair|Function: Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation|Function: May be able to bind plasminogen at cell surface and enhance plasminogen activation.
Gene ID
65137
Gene Name (Vector)
RuvB-like AAA ATPase 1
Gene Symbol
Ruvbl1
ORF Size (aa)
1371
ORF Size (bp)
1371 bp
RefSeq ID
NM_147177
RefSeq Synonyms
NM_147177, BC086531, BC072511,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.