rat SMAD3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Smad3.
shADV-290324
Ad-r-SMAD3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Smad3 (SMAD family member 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
mad3; Madh3; Smad 3
Description (Vector)
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Gene ID
25631
Gene Name (Vector)
SMAD family member 3
Gene Symbol
Smad3
ORF Size (aa)
1278
ORF Size (bp)
1278 bp
RefSeq ID
NM_013095
RefSeq Synonyms
NM_013095, BC064437,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.