rat CAV2 shRNA silencing Adenovirus

Name
Ad-r-CAV2-shRNA

Cat No
shADV-290275

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Rat Cav2.

shADV-290275

Ad-r-CAV2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Rat Cav2 (caveolin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Description (Vector)

CAV2 may act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).

Gene ID

363425

Gene Name (Vector)

caveolin 2

Gene Symbol

Cav2

ORF Size (aa)

489

ORF Size (bp)

489 bp

RefSeq ID

NM_131914

RefSeq Synonyms

NM_131914, BC062059,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.