rat NPM1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Npm1.
shADV-290029
Ad-r-NPM1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Npm1 (nucleophosmin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
B23NP
Description (Vector)
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication.
Gene ID
25498
Gene Name (Vector)
nucleophosmin 1
Gene Symbol
Npm1
ORF Size (aa)
879
ORF Size (bp)
879 bp
RefSeq ID
NM_012992
RefSeq Synonyms
NM_012992, BC088088, BC060579,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.