mouse IPO9 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ipo9.
shADV-280824
Ad-m-IPO9-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ipo9 (importin 9). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
0710008K06Rik; AI845704; C78347; Imp9; mKIAA1192; Ranbp9
Description (Vector)
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6.
Gene ID
226432
Gene Name (Vector)
importin 9
Gene Symbol
Ipo9
ORF Size (aa)
3123
ORF Size (bp)
3123 bp
RefSeq ID
NM_153774
RefSeq Synonyms
NM_153774, BC098508,
Species
mouse
UniGene ID
Mm.271642
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.