mouse BRCA1 shRNA silencing Adenovirus

breast cancer associated 1;breast cancer type 1 susceptibility protein homolog;RING-type E3 ubiquitin transferase BRCA1

BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.

12189

breast cancer 1, early onset

breast cancer 1, early onset

Brca1

10090.0

5436

5436 bp

Breast cancer type 1 susceptibility protein homolog

NM_009764

NM_009764, BC068303,

Aging,Apoptosis,Breast Cancer,Cancer,Cell Cycle,DNA Damage/Repair,Estrogen Signaling,Fanconi anemia,Glioma,Histone Modification,Homologous Recombination,Kinase/Phosphatase,Meiosis,Metabolism/Metabolic Process,MicroRNAs in Cancer,Neurobiology,Nuclear Receptor Coactivators,Phospho-specific,PI3K/Akt Signaling,Prostate Cancer,Replication,RNA Binding,Signal Transduction,TGF-beta Signaling,Transcription Factor / Regulator,Tumor Suppressors/Oncoproteins,Ubiquitination,Zinc-finger

cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,metabolism,neurobiology,signal_transduction,transcription_translation

mouse

BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.

Mm.244975

P48754