mouse DIABLO shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Diablo.
shADV-280496
Ad-m-DIABLO-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Diablo (diablo, IAP-binding mitochondrial protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
0610041G12Rik; 1700006L01Rik; AU040403; Smac
Description (Vector)
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Gene ID
66593
Gene Name (Vector)
diablo, IAP-binding mitochondrial protein
Gene Symbol
Diablo
ORF Size (aa)
714
RefSeq ID
NM_023232
RefSeq Synonyms
NM_023232, BC054109, BC024780,
Species
mouse
UniGene ID
Mm.46716
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.