mouse MYLIP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse MYLIP.
shADV-277759
Ad-m-MYLIP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse MYLIP (myosin regulatory light chain interacting protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
9430057C20Rik; MGC11702; Mir;
Description (Vector)
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Gene ID
218203
Gene Name (Vector)
myosin regulatory light chain interacting protein
Gene Symbol
MYLIP
ORF Size (aa)
1338
ORF Size (bp)
1338 bp
RefSeq ID
NM_153789
RefSeq Synonyms
NM_181043, NM_153789, BC010206,
Species
mouse
UniGene ID
Mm.212855
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.