mouse YAP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Yap1.
shADV-276435
Ad-m-YAP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Yap1 (yes-associated protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI325207; Yap; Yap65; Yki; Yorkie
Description (Vector)
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).
Gene ID
22601
Gene Name (Vector)
yes-associated protein 1
Gene Symbol
Yap1
ORF Size (aa)
1419
ORF Size (bp)
1419 bp
RefSeq ID
NM_009534
RefSeq Synonyms
NM_009534, NM_001171147, BC094313, BC039125, BC014733,
Species
mouse
UniGene ID
Mm.221992
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.