mouse VHL shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Vhl.
shADV-276007
Ad-m-VHL-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Vhl (von Hippel-Lindau tumor suppressor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Vhlh
Description (Vector)
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
Gene ID
22346
Gene Name (Vector)
von Hippel-Lindau tumor suppressor
Gene Symbol
Vhl
ORF Size (aa)
546
RefSeq ID
NM_009507
RefSeq Synonyms
NM_009507, BC052417,
Species
mouse
UniGene ID
Mm.29407
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.