mouse UPF2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Upf2.
shADV-275659
Ad-m-UPF2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Upf2 (UPF2 regulator of nonsense transcripts homolog (yeast)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.
Gene ID
326622
Gene Name (Vector)
UPF2 regulator of nonsense transcripts homolog (yeast)
Gene Symbol
Upf2
ORF Size (aa)
3810
ORF Size (bp)
3810 bp
RefSeq ID
NM_001081132
RefSeq Synonyms
NM_001081132, BC138359, BC138358,
Species
mouse
UniGene ID
Mm.31102
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.