mouse UPF2 Adenovirus

Name
Ad-m-UPF2

Cat No
ADV-275659

Availability
4-5 weeks

This is an Adenovirus expressing Mouse Upf2.

ADV-275659

Ad-m-UPF2

Ready-to-use Adenovirus expressing Mouse Upf2 (UPF2 regulator of nonsense transcripts homolog (yeast)). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Description (Vector)

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.

Gene ID

326622

Gene Name (Vector)

UPF2 regulator of nonsense transcripts homolog (yeast)

Gene Symbol

Upf2

ORF Size (aa)

3810

ORF Size (bp)

3810 bp

RefSeq ID

NM_001081132

RefSeq Synonyms

NM_001081132, BC138359, BC138358,

Species

mouse

UniGene ID

Mm.31102

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.