mouse TXNIP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Txnip.
shADV-275397
Ad-m-TXNIP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Txnip (thioredoxin interacting protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1200008J08Rik; AA682105; Hyplip1; Tbp-2; THIF; VDUP1
Description (Vector)
TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
Gene ID
56338
Gene Name (Vector)
thioredoxin interacting protein
Gene Symbol
Txnip
ORF Size (aa)
1203
RefSeq ID
NM_023719
RefSeq Synonyms
NM_023719, NM_001009935, BC031850, BC011212,
Species
mouse
UniGene ID
Mm.475353
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.