mouse TWIST1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Twist1.
shADV-275367
Ad-m-TWIST1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Twist1 (twist basic helix-loop-helix transcription factor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
bHLHa38; M-Twist; Pde; pdt; Ska10; Ska<m10Jus>; Twist
Description (Vector)
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.
Gene ID
22160
Gene Name (Vector)
twist basic helix-loop-helix transcription factor 1
Gene Symbol
Twist1
ORF Size (aa)
621
ORF Size (bp)
621 bp
RefSeq ID
NM_011658
RefSeq Synonyms
NM_011658, BC083139, BC033434,
Species
mouse
UniGene ID
Mm.3280
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.