mouse TRIM13 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Trim13.
shADV-274965
Ad-m-TRIM13-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Trim13 (tripartite motif-containing 13). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3110001L12Rik; CAR; LEU5; Rfp2; RNF77
Description (Vector)
E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.
Gene ID
66597
Gene Name (Vector)
tripartite motif-containing 13
Gene Symbol
Trim13
ORF Size (aa)
1224
ORF Size (bp)
1224 bp
RefSeq ID
NM_023233
RefSeq Synonyms
NM_023233, NM_001164220, BC145915, BC138576,
Species
mouse
UniGene ID
Mm.475709
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.