mouse TEAD1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Tead1.
shADV-274004
Ad-m-TEAD1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Tead1 (TEA domain family member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610024B07Rik; B230114H05Rik; Gtrgeo5; mTEF-1; Tcf13; TEAD-1; TEF-1
Description (Vector)
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Gene ID
21676
Gene Name (Vector)
TEA domain family member 1
Gene Symbol
Tead1
ORF Size (aa)
1236
RefSeq ID
NM_009346
RefSeq Synonyms
NM_009346, NM_001166585, NM_001166584, BC060138,
Species
mouse
UniGene ID
Mm.28081
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.