mouse SMARCA2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Smarca2.
shADV-272610
Ad-m-SMARCA2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Smarca2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610209L14Rik; brahma; brm; SNF2alpha; Snf2l2
Description (Vector)
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Gene ID
67155
Gene Name (Vector)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Gene Symbol
Smarca2
ORF Size (aa)
4734
ORF Size (bp)
4734 bp
RefSeq ID
NM_011416
RefSeq Synonyms
NM_026003, NM_011416, NM_001347439, BC075641,
Species
mouse
UniGene ID
Mm.477499
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.