mouse RTN4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Rtn4.
shADV-271222
Ad-m-RTN4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Rtn4 (reticulon 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C; NSP-CL
Description (Vector)
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
Gene ID
68585
Gene Name (Vector)
reticulon 4
Gene Symbol
Rtn4
ORF Size (aa)
1920
ORF Size (bp)
1920 bp
RefSeq ID
NM_194054
RefSeq Synonyms
NM_194054, NM_194053, NM_194052, NM_194051, NM_024226, BC032192,
Species
mouse
UniGene ID
Mm.475165
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.