mouse RAD50 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Rad50.
shADV-270061
Ad-m-RAD50-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Rad50 (RAD50 double strand break repair protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Mrell; Rad50l
Description (Vector)
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Gene ID
19360
Gene Name (Vector)
RAD50 double strand break repair protein
Gene Symbol
Rad50
ORF Size (aa)
3939
ORF Size (bp)
3939 bp
RefSeq ID
NM_009012
RefSeq Synonyms
NM_009012, BC168398,
Species
mouse
UniGene ID
Mm.477255
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.