mouse PTTG1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Pttg1.
shADV-269846
Ad-m-PTTG1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Pttg1 (pituitary tumor-transforming gene 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW555095; C87862; Pttg; Pttg3
Description (Vector)
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
Gene ID
30939
Gene Name (Vector)
pituitary tumor-transforming gene 1
Gene Symbol
Pttg1
ORF Size (aa)
600
RefSeq ID
NM_013917
RefSeq Synonyms
NM_013917, NM_001131054, BC023324,
Species
mouse
UniGene ID
Mm.6856
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.