mouse PPAP2A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Plpp1.
shADV-269114
Ad-m-PPAP2A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Plpp1 (phospholipid phosphatase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a; PAP2-alpha; PAP2a; Ppap2a
Description (Vector)
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
Gene ID
19012
Gene Name (Vector)
phospholipid phosphatase 1
Gene Symbol
Plpp1
ORF Size (aa)
855
ORF Size (bp)
855 bp
RefSeq ID
NM_008247
RefSeq Synonyms
NM_008903, NM_008247, BC061161,
Species
mouse
UniGene ID
Mm.317186
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.