mouse PODXL shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Podxl.
shADV-268985
Ad-m-PODXL-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Podxl (podocalyxin-like). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW121214; Ly102; PC; PCLP-1; Pclp1
Description (Vector)
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Gene ID
27205
Gene Name (Vector)
podocalyxin-like
Gene Symbol
Podxl
ORF Size (aa)
1512
ORF Size (bp)
1512 bp
RefSeq ID
NM_013723
RefSeq Synonyms
NM_013723, BC054530, BC052442,
Species
mouse
UniGene ID
Mm.89918
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.