mouse PIN1 shRNA silencing Adenovirus

Name 
Ad-m-PIN1-shRNA
Cat No 
shADV-268672
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Pin1.

shADV-268672
Ad-m-PIN1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Pin1 (protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
0610025L01Rik; D9Bwg1161e
Description (Vector)
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.
Gene ID
23988
Gene Name (Vector)
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
Gene Symbol
Pin1
ORF Size (aa)
498
RefSeq ID
NM_023371
RefSeq Synonyms
NM_023371, BC038254,
Species
mouse
UniGene ID
Mm.7906

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.