mouse P4HTM shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse P4htm.
shADV-267967
Ad-m-P4HTM-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse P4htm (prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4933406E20Rik; AI853847; BB128974; Ph-4
Description (Vector)
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Gene ID
74443
Gene Name (Vector)
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Gene Symbol
P4htm
ORF Size (aa)
1512
ORF Size (bp)
1512 bp
RefSeq ID
NM_028944
RefSeq Synonyms
NM_028944, BC111871,
Species
mouse
UniGene ID
Mm.226534
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.