mouse NRG1 shRNA silencing Adenovirus

Name
Ad-m-NRG1-shRNA

Cat No
shADV-266077

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Mouse Nrg1.

shADV-266077

Ad-m-NRG1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nrg1 (neuregulin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

6030402G23Rik; ARIA; D230005F13Rik; GGF; GGFII; Hgl; HRG; HRGalpha; NDF; SMDF

Description (Vector)

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Gene ID

211323

Gene Name (Vector)

neuregulin 1

Gene Symbol

Nrg1

ORF Size (aa)

2103

ORF Size (bp)

2103 bp

RefSeq ID

NM_178591

RefSeq Synonyms

NM_178591, BC160344, BC151113,

Species

mouse

UniGene ID

Mm.460675

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.