mouse NPM1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Npm1.
shADV-265994
Ad-m-NPM1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Npm1 (nucleophosmin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
B23; NO38; Npm
Description (Vector)
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication.
Gene ID
18148
Gene Name (Vector)
nucleophosmin 1
Gene Symbol
Npm1
ORF Size (aa)
774
ORF Size (bp)
774 bp
RefSeq ID
NM_008722
RefSeq Synonyms
NM_008722, NM_001252261, NM_001252260, BC092378, BC090843, BC089546, BC085278, BC054755,
Species
mouse
UniGene ID
Mm.6343
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.