mouse NEDD4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Nedd4.
shADV-265628
Ad-m-NEDD4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nedd4 (neural precursor cell expressed, developmentally down-regulated 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AA959633; AL023035; AU019897; E430025J12Rik; mKIAA0093; Nedd4-1; Nedd4a
Description (Vector)
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.
Gene ID
17999
Gene Name (Vector)
neural precursor cell expressed, developmentally down-regulated 4
Gene Symbol
Nedd4
ORF Size (aa)
2664
ORF Size (bp)
2664 bp
RefSeq ID
NM_010890
RefSeq Synonyms
NM_010890, BC138813,
Species
mouse
UniGene ID
Mm.279923
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.