mouse MBNL2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Mbnl2.
shADV-264325
Ad-m-MBNL2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Mbnl2 (muscleblind-like 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110002M11Rik; AI047808; AI837313; AI849185; AL118326; MBLL; mKIAA4072; R75232
Description (Vector)
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulates expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).
Gene ID
105559
Gene Name (Vector)
muscleblind-like 2
Gene Symbol
Mbnl2
ORF Size (aa)
1122
ORF Size (bp)
1122 bp
RefSeq ID
NM_207515
RefSeq Synonyms
NM_207515, NM_175341, BC075665,
Species
mouse
UniGene ID
Mm.400294
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.