mouse MAGOH shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse MAGOH.
shADV-264130
Ad-m-MAGOH-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse MAGOH (mago-nashi homolog, proliferation-associated (Drosophila)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Mago-m; Mos2;
Description (Vector)
Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA after its export to the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex.
Gene ID
17149
Gene Name (Vector)
mago-nashi homolog, proliferation-associated (Drosophila)
Gene Symbol
MAGOH
ORF Size (aa)
441
ORF Size (bp)
441 bp
RefSeq ID
NM_010760
RefSeq Synonyms
NM_010760, NM_001282737, BC018176,
Species
mouse
UniGene ID
Mm.808
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.