mouse LCN2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Lcn2.
shADV-263329
Ad-m-LCN2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Lcn2 (lipocalin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
24p3; AW212229; NRL; Sip24
Description (Vector)
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
Gene ID
16819
Gene Name (Vector)
lipocalin 2
Gene Symbol
Lcn2
ORF Size (aa)
603
RefSeq ID
NM_008491
RefSeq Synonyms
NM_008491, BC132071, BC132069,
Species
mouse
UniGene ID
Mm.9537
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.