mouse KPNB1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Kpnb1.
shADV-263042
Ad-m-KPNB1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Kpnb1 (karyopherin (importin) beta 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AA409963; Impnb; IPOB
Description (Vector)
Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus.
Gene ID
16211
Gene Name (Vector)
karyopherin (importin) beta 1
Gene Symbol
Kpnb1
ORF Size (aa)
2631
ORF Size (bp)
2631 bp
RefSeq ID
NM_008379
RefSeq Synonyms
NM_008379, BC055115, BC052711, BC052438,
Species
mouse
UniGene ID
Mm.251013
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.