mouse KPNA3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Kpna3.
shADV-263038
Ad-m-KPNA3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Kpna3 (karyopherin (importin) alpha 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IPOA4
Description (Vector)
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.
Gene ID
16648
Gene Name (Vector)
karyopherin (importin) alpha 3
Gene Symbol
Kpna3
ORF Size (aa)
1566
ORF Size (bp)
1566 bp
RefSeq ID
NM_008466
RefSeq Synonyms
NM_008466, BC026885,
Species
mouse
UniGene ID
Mm.25548
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.