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human KPNA3 Adenovirus

Name 
Ad-h-KPNA3
Cat No 
ADV-213343
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human KPNA3.

ADV-213343
Ad-h-KPNA3

Ready-to-use Adenovirus expressing Human KPNA3 (karyopherin subunit alpha 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
hSRP1; importin alpha 4; importin alpha Q2; importin alpha-3; importin subunit alpha-3; importin subunit alpha-4; IPOA4; karyopherin alpha 3 (importin alpha 4); Karyopherin subunit alpha-3; qip2; SRP1; SRP1gamma; SRP1-gamma; SRP4
Description (eCommerce)
KPNA3 (karyopherin alpha 3), also known as importin alpha 4, is a member of the importin alpha family of proteins which includes KPNA1 (importin alpha 5), KPNA2 (importin alpha 1), KPNA3 (importin alpha 4), KPNA4 (importin alpha 3), KPNA5 (importin alpha 6), and KPNA6 (importin alpha 7). The importin alpha family of proteins plays a role in the import of proteins from the cytoplasm to the nucleus. The import of proteins from the cytoplasm to the nucleus involves docking the protein to receptors associated with the nuclear pore complex (NPC) followed by translocation through the nuclear pore. Importin alpha proteins bind the nuclear localization signal (NLS) of cargo proteins and function as adaptor proteins for the nuclear pore receptor KPNB1 (importin beta 1). KPNB1 is responsible for docking the importin-cargo complex to the cytoplasmic side of the NPC for its translocation through the NPC. KPNA3 (Importin alpha 4) and KPNA4 (importin alpha 3) have been reported to mediate the nuclear import of TNF-alpha induced nuclear import of NF-kappaB p50/p65 heterodimers. KPNA3 has also been reported to be responsible for the ligand-independent nuclear translocation of the vitamin D receptor.
Description (Vector)
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import.
Gene ID
3839
Gene Name (eCommerce)
karyopherin subunit alpha 3
Gene Name (Vector)
karyopherin subunit alpha 3
Gene Symbol
KPNA3
HGNC ID
HGNC:6396
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1566
ORF Size (bp)
1566 bp
Protein Name (eCommerce)
Importin subunit alpha-4
RefSeq ID
NM_002267
RefSeq Synonyms
NM_002267, BC035090, BC024202, BC017355,
Research Areas
Host-Virus Interactions,Immunology,Neurobiology,Signal Transduction,TNF Signaling,Transport
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
KPNA3 (karyopherin alpha 3), also known as importin alpha 4, is a member of the importin alpha family of proteins which includes KPNA1 (importin alpha 5), KPNA2 (importin alpha 1), KPNA3 (importin alpha 4), KPNA4 (importin alpha 3), KPNA5 (importin alpha 6), and KPNA6 (importin alpha 7). The importin alpha family of proteins plays a role in the import of proteins from the cytoplasm to the nucleus. The import of proteins from the cytoplasm to the nucleus involves docking the protein to receptors associated with the nuclear pore complex (NPC) followed by translocation through the nuclear pore. Importin alpha proteins bind the nuclear localization signal (NLS) of cargo proteins and function as adaptor proteins for the nuclear pore receptor KPNB1 (importin beta 1). KPNB1 is responsible for docking the importin-cargo complex to the cytoplasmic side of the NPC for its translocation through the NPC. KPNA3 (Importin alpha 4) and KPNA4 (importin alpha 3) have been reported to mediate the nuclear import of TNF-alpha induced nuclear import of NF-kappaB p50/p65 heterodimers. KPNA3 has also been reported to be responsible for the ligand-independent nuclear translocation of the vitamin D receptor.
UniGene ID
Hs.527919
UniProt ID (eCommerce)
O00505

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.