mouse KCNQ2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse KCNQ2.
shADV-262705
Ad-m-KCNQ2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse KCNQ2 (potassium voltage-gated channel, subfamily Q, member 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HNSPC; KQT2; Nmf134
Description (Vector)
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.
Gene ID
16536
Gene Name (Vector)
potassium voltage-gated channel, subfamily Q, member 2
Gene Symbol
KCNQ2
ORF Size (aa)
2610
ORF Size (bp)
2610 bp
RefSeq ID
NM_001006674
RefSeq Synonyms
NM_010611, NM_001302888, NM_001006680, NM_001006679, NM_001006678, NM_001006677, NM_001006676, NM_001006675, NM_001006674, NM_001006669, NM_001006668, NM_001003825, NM_001003824, BC156315, BC145453,
Species
mouse
UniGene ID
Mm.440175
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.