human KCNQ2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human KCNQ2.
shAAV-212772
AAV-h-KCNQ2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human KCNQ2 (potassium voltage-gated channel subfamily Q member 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KV7.2
Description (Vector)
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Gene ID
3785
Gene Name (Vector)
potassium voltage-gated channel subfamily Q member 2
Gene Symbol
KCNQ2
HGNC ID
HGNC:6296
ORF Size (aa)
2616
ORF Size (bp)
2616 bp
RefSeq ID
NM_004518
RefSeq Synonyms
NM_172109, NM_172108, NM_172107, NM_172106, NM_004518, BC146294, BC000699,
Species
human
UniGene ID
Hs.652468
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.