mouse IPO13 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ipo13.
shADV-262318
Ad-m-IPO13-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ipo13 (importin 13). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Imp13; Kap13; Ranbp13
Description (Vector)
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
Gene ID
230673
Gene Name (Vector)
importin 13
Gene Symbol
Ipo13
ORF Size (aa)
2892
ORF Size (bp)
2892 bp
RefSeq ID
NM_146152
RefSeq Synonyms
NM_146152, BC031823,
Species
mouse
UniGene ID
Mm.287810
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.