mouse ILK shRNA silencing Adenovirus

Name
Ad-m-ILK-shRNA

Cat No
shADV-262206

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Mouse Ilk.

shADV-262206

Ad-m-ILK-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ilk (integrin linked kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

AA511515; ESTM24

Description (Vector)

Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Gene ID

16202

Gene Name (Vector)

integrin linked kinase

Gene Symbol

Ilk

ORF Size (aa)

1359

ORF Size (bp)

1359 bp

RefSeq ID

NM_010562

RefSeq Synonyms

NM_010562, NM_001161724, BC003737,

Species

mouse

UniGene ID

Mm.274846

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.