mouse IL1R1 shRNA silencing Adenovirus

Name
Ad-m-IL1R1-shRNA

Cat No
shADV-262138

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Mouse Il1r1.

shADV-262138

Ad-m-IL1R1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Il1r1 (interleukin 1 receptor, type I). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CD121a; CD121b; IL-1R1; IL-iR; Il1r-1

Description (Vector)

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Gene ID

16177

Gene Name (Vector)

interleukin 1 receptor, type I

Gene Symbol

Il1r1

ORF Size (aa)

1731

ORF Size (bp)

1731 bp

RefSeq ID

NM_008362

RefSeq Synonyms

NM_008362, NM_001123382, BC109135,

Species

mouse

UniGene ID

Mm.896

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.