mouse HACE1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Hace1.
shADV-261082
Ad-m-HACE1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Hace1 (HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1700042J16Rik; A730034A22Rik; BC025474
Description (Vector)
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
Gene ID
209462
Gene Name (Vector)
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Gene Symbol
Hace1
ORF Size (aa)
2730
ORF Size (bp)
2730 bp
RefSeq ID
NM_172473
RefSeq Synonyms
NM_172473, BC120697, BC120695,
Species
mouse
UniGene ID
Mm.458633
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.