mouse H3F3B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse H3f3b.
shADV-261074
Ad-m-H3F3B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse H3f3b (H3 histone, family 3B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
9430068D06Rik; H3.3B
Description (Vector)
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Gene ID
15081
Gene Name (Vector)
H3 histone, family 3B
Gene Symbol
H3f3b
ORF Size (aa)
417
RefSeq ID
NM_008211
RefSeq Synonyms
NM_008211, BC092300, BC092043, BC037730, BC021768,
Species
mouse
UniGene ID
Mm.371563
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.