mouse FNDC5 shRNA silencing Adenovirus

Name 
Ad-m-FNDC5-shRNA
Cat No 
shADV-259530
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Fndc5.

shADV-259530
Ad-m-FNDC5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Fndc5 (fibronectin type III domain containing 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
plasmin; plasminogen
Description (eCommerce)
The exercise-inducible myokine Irisin (Boström, et al. 2012) is secreted by cleavage from the transmembrane precursor, FNDC5. Circulating Irisin govern a wide variety of cellular processes relevant to browning, angiogenesis, wound healing, bone mass, and metabolism.
Description (Vector)
Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA (By similarity).
Gene ID
384061
Gene Name (eCommerce)
fibronectin type III domain containing 5
Gene Name (Vector)
fibronectin type III domain containing 5
Gene Symbol
Fndc5
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
630
Protein Name (eCommerce)
Fibronectin type III domain-containing protein 5
RefSeq ID
NM_027402
RefSeq Synonyms
NM_027402, BC109184, BC109183,
Research Areas
Cardiovascular
Research Areas (Faceted)
cardiovascular
Species
mouse
Target Sentence
The exercise-inducible myokine Irisin (Boström, et al. 2012) is secreted by cleavage from the transmembrane precursor, FNDC5. Circulating Irisin govern a wide variety of cellular processes relevant to browning, angiogenesis, wound healing, bone mass, and metabolism.
UniGene ID
Mm.44075
UniProt ID (eCommerce)
Q8K4Z2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.