mouse EYA3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Eya3.
shADV-258818
Ad-m-EYA3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Eya3 (EYA transcriptional coactivator and phosphatase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI844637
Description (Vector)
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
Gene ID
14050
Gene Name (Vector)
EYA transcriptional coactivator and phosphatase 3
Gene Symbol
Eya3
ORF Size (aa)
1581
ORF Size (bp)
1581 bp
RefSeq ID
NM_010166
RefSeq Synonyms
NM_211357, NM_210071, NM_010166, BC063259,
Species
mouse
UniGene ID
Mm.227733
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.