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human EYA3 shRNA silencing AAV

Name 
AAV-h-EYA3-shRNA
Cat No 
shAAV-208210
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human EYA3.

shAAV-208210
AAV-h-EYA3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EYA3 (EYA transcriptional coactivator and phosphatase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
77
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
eyes absent 3; eyes absent homolog 3
Description (eCommerce)
EYA3 (eyes absent homolog 3) functions as a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). EYA3 promotes efficient DNA repair by dephosphorylating H2AX and promoting the recruitment of DNA repair complexes containing MDC1. EYA3 coactivates SIX1. Together with SIX1 and DACH2 EYA3 seems to be involved in myogenesis. EYA3 may be involved in development of the eye [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q99504].
Description (Vector)
EYA3 encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. A similar protein in mice acts as a transcriptional activator.
Gene ID
2140
Gene Name (eCommerce)
EYA transcriptional coactivator and phosphatase 3
Gene Name (Vector)
EYA transcriptional coactivator and phosphatase 3
Gene Symbol
EYA3
HGNC ID
HGNC:3521
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1611
ORF Size (bp)
1611 bp
Protein Name (eCommerce)
Eyes absent homolog 3
RefSeq ID
NM_001990
RefSeq Synonyms
NM_001990, NM_001282562, NM_001282561, NM_001282560, BC041667, BC029500,
Research Areas
Chromatin Remodeling,DNA Damage/Repair,Histone Modification,Kinase/Phosphatase,Neurobiology,Phosphatase,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
EYA3 (eyes absent homolog 3) functions as a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). EYA3 promotes efficient DNA repair by dephosphorylating H2AX and promoting the recruitment of DNA repair complexes containing MDC1. EYA3 coactivates SIX1. Together with SIX1 and DACH2 EYA3 seems to be involved in myogenesis. EYA3 may be involved in development of the eye [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q99504].
UniGene ID
Hs.185774
UniProt ID (eCommerce)
Q99504

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.