mouse ADAM15 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Adam15.
shADV-258517
Ad-m-ADAM15-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Adam15 (a disintegrin and metallopeptidase domain 15 (metargidin)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AD56; MDC15
Description (Vector)
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Gene ID
11490
Gene Name (Vector)
a disintegrin and metallopeptidase domain 15 (metargidin)
Gene Symbol
Adam15
ORF Size (aa)
1347
ORF Size (bp)
1347 bp
RefSeq ID
NM_009614
RefSeq Synonyms
NM_009614, NM_001037722, BC009132,
Species
mouse
UniGene ID
Mm.470104
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.