mouse EFNA5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Efna5.
shADV-257817
Ad-m-EFNA5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Efna5 (ephrin A5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AL-1; AV158822; EFL-5; Ephrin-A5; Epl7; LERK-7; RAGS
Description (Vector)
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
Gene ID
13640
Gene Name (Vector)
ephrin A5
Gene Symbol
Efna5
ORF Size (aa)
687
ORF Size (bp)
687 bp
RefSeq ID
NM_010109
RefSeq Synonyms
NM_207654, NM_010109, BC040218,
Species
mouse
UniGene ID
Mm.471638
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.