human EFNA5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human EFNA5.
shAAV-207637
AAV-h-EFNA5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human EFNA5 (ephrin A5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AF1; EFL5; EPLG7; GLC1M; LERK7; RAGS
Description (Vector)
Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Gene ID
1946
Gene Name (Vector)
ephrin A5
Gene Symbol
EFNA5
HGNC ID
HGNC:3225
ORF Size (aa)
687
ORF Size (bp)
687 bp
RefSeq ID
NM_001962
RefSeq Synonyms
NM_001962, BC075055, BC075054,
Species
human
UniGene ID
Hs.288741
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.