mouse DIAP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Diaph1.
shADV-257172
Ad-m-DIAP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Diaph1 (diaphanous related formin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D18Wsu154e; Dia1; Diap1; Drf1; p140mDia
Description (Vector)
Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Gene ID
13367
Gene Name (Vector)
diaphanous related formin 1
Gene Symbol
Diaph1
ORF Size (aa)
3663
ORF Size (bp)
3663 bp
RefSeq ID
NM_007858
RefSeq Synonyms
NM_007858, NM_001305981, NM_001305980, BC070412,
Species
mouse
UniGene ID
Mm.195916
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.