mouse DACH1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Dach1.
shADV-256782
Ad-m-DACH1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Dach1 (dachshund 1 (Drosophila)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Dac; Dach
Description (Vector)
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).
Gene ID
13134
Gene Name (Vector)
dachshund 1 (Drosophila)
Gene Symbol
Dach1
ORF Size (aa)
2100
ORF Size (bp)
2100 bp
RefSeq ID
NM_007826
RefSeq Synonyms
NM_007826, NM_001038610, BC141130,
Species
mouse
UniGene ID
Mm.320593
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.